Morita T, Tsuchiya N, Tsujii T, Kondo S
Department of Urology, Tokyo Medical and Dental University School of Medicine.
Tohoku J Exp Med. 1992 Mar;166(3):403-5. doi: 10.1620/tjem.166.403.
Effects of castration and estrogen administration on the distribution of autonomic receptors in the male rabbit urethral smooth muscle were examined. Thirty-eight mature Japanese white rabbits were used. Eight rabbits were used as untreated control. The other 30 rabbits were castrated and 10 of them were administered intramuscularly with 5 mg/kg estrogen 3 times a week for 4 weeks from 12 weeks after castration. Autonomic receptor densities in the urethral smooth muscle were measured by radioligand binding techniques. alpha 1-Adrenergic and muscarinic cholinergic receptor densities decreased significantly after castration and were not affected by estrogen administration. alpha 2-Adrenergic receptor density increased slightly after castration and markedly after estrogen administration. beta-Adrenergic receptors were not affected either by castration or estrogen administration. No significant changes were observed in any receptor affinities. These results demonstrate the effects of castration and estrogen administration on the autonomic receptors in the male rabbit urethral smooth muscle.
研究了去势和给予雌激素对雄性兔尿道平滑肌自主神经受体分布的影响。使用了38只成年日本白兔。8只兔子作为未处理的对照。另外30只兔子去势，其中10只在去势后12周开始每周3次肌肉注射5mg/kg雌激素，共4周。通过放射性配体结合技术测量尿道平滑肌中的自主神经受体密度。去势后α1-肾上腺素能和毒蕈碱胆碱能受体密度显著降低，且不受雌激素给药的影响。去势后α2-肾上腺素能受体密度略有增加，给予雌激素后显著增加。β-肾上腺素能受体既不受去势影响，也不受雌激素给药影响。任何受体亲和力均未观察到显著变化。这些结果证明了去势和给予雌激素对雄性兔尿道平滑肌自主神经受体的影响。
