Climent Duran M A, Germa Lluch J R, Seguí Palmer M A, Fernández Sagarra A, Izquierdo Delso M A, Lacasta Muñoa A
Servicio de Oncología, Hospital de la Santa Creu i Sant Pau, Barcelona, España.
Arch Esp Urol. 1992 Jan-Feb;45(1):21-4.
From 1984 to 1989, 89 patients with stage I testicular carcinoma had been treated and followed at the Oncology Unit of the "Santa Creu i Sant Pau" Hospital. The histologic diagnosis was that of seminoma in 53 and nonseminomatous tumor in 36 patients. Treatment considered of inguinal orchidectomy and close clinical surveillance. Eight of the patients that had been diagnosed as having seminoma received adjuvant radiotherapy since follow-up could not be possible. Recurrence was observed in 5 of the 45 (11 por 100) patients with seminoma and 11 of the 36 (31 por 100) with nonseminomatous tumor that could be followed. All recurrences received chemotherapy (cisplatin and etoposide) which achieved complete remission. All of the patients are currently tumor-free after a mean follow-up of 34 months for the patients with seminoma, 39 months for those with nonseminomatous tumor and no recurrence, and 20 months for the nonseminomatous tumors that had recurred. Surveillance following orchidectomy for stage I testicular tumors is a valid approach if the patient can be followed correctly and achieves the same results as other more aggressive therapeutic strategies.
1984年至1989年期间,“圣十字圣保罗”医院肿瘤科对89例I期睾丸癌患者进行了治疗和随访。组织学诊断为精原细胞瘤的有53例,非精原细胞瘤的有36例。治疗方法包括腹股沟睾丸切除术和密切的临床监测。8例被诊断为精原细胞瘤的患者由于无法进行随访而接受了辅助放疗。在45例(每100例中有11例)可随访的精原细胞瘤患者中,有5例复发;在36例(每100例中有31例)可随访的非精原细胞瘤患者中,有11例复发。所有复发病例均接受了化疗(顺铂和依托泊苷),并实现了完全缓解。目前,精原细胞瘤患者平均随访34个月、非精原细胞瘤患者平均随访39个月且无复发以及复发性非精原细胞瘤患者平均随访20个月后,所有患者均无肿瘤。如果患者能够得到正确随访,睾丸切除术治疗I期睾丸肿瘤后的监测是一种有效的方法,并且能取得与其他更积极治疗策略相同的效果。