Adami H O, Glimelius B, Sparén P, Holmberg L, Krusemo U B, Pontén J
Cancer Epidemiology Unit, University Hospital, Uppsala, Sweden.
Acta Oncol. 1992;31(1):1-10. doi: 10.3109/02841869209088258.
The temporal changes in childhood and adolescent cancer survival in Sweden 1960-1984 were analyzed. Complete follow-up through 1986 of 6,262 patients younger than 20 years at diagnosis revealed that the overall 5-year survival rates increased from 36.1 to 65.7% in males and from 43.6 to 73.6% in females. The temporal trends differed markedly between age groups and tumour sites and types. Over the study period, 5-years, survival for testicular cancer increased from 46.9 to 87.2%, kidney cancer, predominantly Wilms' tumour from 35.5 to 77.1% (with a higher rate of 89.1% in 1975-1979), Hodgkin's disease from 61.2 to 91.9%, non-Hodgkin's lymphoma from 32.5 to 76.6%, and all leukemias from 8.9 to 58.7%. Only a moderate improvement was noted for tumours of the bone, muscle and connective tissue, and survival rates for tumours of the nervous system remained largely unchanged. Our data reflect the remarkable therapeutic improvements that have occurred for cancer in the young and indicate that these improvements have rapidly become available in Sweden.
对1960 - 1984年瑞典儿童和青少年癌症生存率的时间变化进行了分析。对确诊时年龄小于20岁的6262例患者进行了至1986年的完整随访，结果显示男性的总体5年生存率从36.1%提高到了65.7%，女性从43.6%提高到了73.6%。年龄组、肿瘤部位和类型之间的时间趋势差异显著。在研究期间，睾丸癌的5年生存率从46.9%提高到了87.2%，肾癌（主要是肾母细胞瘤）从35.5%提高到了77.1%（1975 - 1979年期间更高，为89.1%），霍奇金病从61.2%提高到了91.9%，非霍奇金淋巴瘤从32.5%提高到了76.6%，所有白血病从8.9%提高到了58.7%。骨、肌肉和结缔组织肿瘤仅出现了适度改善，神经系统肿瘤的生存率基本保持不变。我们的数据反映了在年轻人癌症治疗方面取得的显著进展，并表明这些进展在瑞典已迅速普及。
