Köhler E, Knospe S, Schäfer H, Dorsche H H, Hahn H J, Fiedler H
Endokrinologie. 1975 Sep;66(1):31-45.
The glucose utilization by different skeletal muscle tissues of short-term streptozotocin treated Wistar rats was studied both in vivo and in vitro. The findings permit the following statements: The reduced metabolic conversion of glucose is mainly the result of the diminished transport of glucose into the muscle cells. The utilization of the glucose taken up by the muscle cells for synthesis of glycogen is unchanged in the diabetic animals and can be stimulated by insulin correspondingly as in normal rats. The conversion of the glucose metabolized by the cells to lactate and the time course of the specific activity of glycogen and lactate lead to the conclusion that glycogenolysis in the muscles of streptozotocin diabetic rats during the incubation is enhanced.
研究了短期链脲佐菌素处理的Wistar大鼠不同骨骼肌组织在体内和体外的葡萄糖利用情况。研究结果如下：葡萄糖代谢转化减少主要是由于葡萄糖进入肌肉细胞的转运减少所致。糖尿病动物中，肌肉细胞摄取的葡萄糖用于糖原合成的利用率未发生变化，且与正常大鼠一样，可被胰岛素相应刺激。细胞代谢的葡萄糖转化为乳酸以及糖原和乳酸比活性的时间进程表明，链脲佐菌素糖尿病大鼠肌肉在孵育期间糖原分解增强。
