正常大鼠、链脲佐菌素处理的糖尿病大鼠以及抗胰岛素血清处理的大鼠膈肌中葡萄糖的代谢。
The metabolism of glucose in diaphragm muscle from normal rats, from streptozotocin-treated diabetic rats and from rats treated with anti-insulin serum.
作者信息
Beloff-Chain A, Rookledge K A
出版信息
Biochem J. 1968 Dec;110(3):529-32. doi: 10.1042/bj1100529.
Abstract
- The metabolism of [U-(14)C]glucose by the isolated diaphragm muscle of normal rats, rats rendered diabetic with streptozotocin and rats with transitory insulin deficiency after an injection of anti-insulin serum was studied. 2. The incorporation of [(14)C]glucose into glycogen and oligosaccharides was significantly decreased in the diabetic diaphragm muscle and in the muscle from rats treated with anti-insulin serum. 3. Neither diabetes nor transitory insulin deficiency influenced the oxidation of glucose, or the formation of lactate and hexose phosphate esters from glucose. 4. Insulin fully restored the incorporation of glucose into glycogen and maltotetraose in the diabetic muscle, but the incorporation into oligosaccharides, although increased in the presence of insulin, was significantly lower than the values obtained with normal diaphragm in the presence of insulin.
摘要
- 研究了正常大鼠、经链脲佐菌素诱导糖尿病的大鼠以及注射抗胰岛素血清后出现短暂胰岛素缺乏的大鼠的离体膈肌对[U-(14)C]葡萄糖的代谢情况。2. 在糖尿病膈肌以及经抗胰岛素血清处理的大鼠的肌肉中，[(14)C]葡萄糖掺入糖原和寡糖的量显著降低。3. 糖尿病和短暂胰岛素缺乏均未影响葡萄糖的氧化，也未影响由葡萄糖形成乳酸和己糖磷酸酯。4. 胰岛素能完全恢复糖尿病肌肉中葡萄糖掺入糖原和麦芽四糖的情况，但葡萄糖掺入寡糖的量虽在胰岛素存在时有所增加，却仍显著低于正常膈肌在胰岛素存在时的数值。
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本文引用的文献
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Proc R Soc Lond B Biol Sci. 1955 May 17;143(913):481-503. doi: 10.1098/rspb.1955.0025.
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