Ophir A, Chevion M
Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.
Ophthalmic Surg. 1992 Apr;23(4):284-7.
Oxygen-derived free radicals have been implicated in tissue injury following ischemia and reperfusion (reoxygenation). It has been hypothesized that the radicals are produced during the early reperfusion stage. Recently, submacular implantation of retinal pigment epithelium cells has been reported. It is probable that during the procedure, the transplant and the 180-degree folded outer retina underwent a period of ischemia, followed by reoxygenation. We, therefore, infer that free radicals were produced during the reoxygenation stage of the procedure, injuring both tissues. We suggest that these hypotheses be investigated with the aim of improving the surgical outcome in eyes with age-related macular degeneration.
氧衍生的自由基与缺血再灌注（复氧）后的组织损伤有关。据推测，自由基是在再灌注早期阶段产生的。最近，有报道称视网膜色素上皮细胞进行了黄斑下植入。在该手术过程中，移植组织和180度折叠的外层视网膜可能经历了一段时间的缺血，随后是复氧。因此，我们推断在该手术的复氧阶段产生了自由基，对这两种组织都造成了损伤。我们建议对这些假设进行研究，以改善年龄相关性黄斑变性患者眼睛的手术效果。
