Dudchenko P, Sarter M
Department of Psychology, Ohio State University, Columbus 43210.
Behav Brain Res. 1992 Apr 10;47(2):202-5. doi: 10.1016/s0166-4328(05)80127-5.
Bilateral infusion of the GABAA-receptor agonist muscimol into the basal forebrain was previously found to impair visual conditional discrimination performance in rats. In order to examine whether the GABAergic input into the basal forebrain is active during performance of this task, the benzodiazepine receptor agonist chlordiazepoxide (15, 25, 40 micrograms/0.5 microliters/hemisphere) was bilaterally infused. Surprisingly, chlordiazepoxide did not affect performance. The impact of this result for the understanding of basal forebrain GABAergic functions is discussed.
先前发现，向大鼠基底前脑双侧注射γ-氨基丁酸A型（GABAA）受体激动剂蝇蕈醇会损害其视觉条件辨别能力。为了研究在执行该任务期间，基底前脑的γ-氨基丁酸能（GABAergic）输入是否活跃，研究人员双侧注射了苯二氮䓬受体激动剂氯氮䓬（15、25、40微克/0.5微升/半球）。令人惊讶的是，氯氮䓬并未影响大鼠的表现。本文讨论了这一结果对理解基底前脑GABA能功能的影响。
