大鼠肝脏在体外形成的大麻酚二羟基化代谢产物。
Dihydroxylated metabolites of cannabinol formed by rat liver in vitro.
作者信息
Fonseka K, Widman M
出版信息
J Pharm Pharmacol. 1977 Jan;29(1):12-4. doi: 10.1111/j.2042-7158.1977.tb11229.x.
Abstract
Cannabinol (CBN) was metabolized in vitro by a 10,000 g supernatant from rat liver. After removal of unchanged CBN and its monohydroxylated metabolites four dihydroxylated metabolites were isolated. By nuclear magnetic resonance and mass spectrometry the compounds were identified as 1'',7-dihydroxy-CBN. Side chain hydroxylation occurred predominantly at C-4'' anc C-3''.
摘要
大麻酚（CBN）在体外被大鼠肝脏的10,000g上清液代谢。去除未变化的CBN及其单羟基化代谢物后，分离出四种二羟基化代谢物。通过核磁共振和质谱法，这些化合物被鉴定为1'',7-二羟基-CBN。侧链羟基化主要发生在C-4''和C-3''位。
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