从大鼠粪便中分离出的大麻酚的体内中性代谢物。

Neutral in vivo metabolites of cannabinol isolated from rat faeces.

作者信息

Yisak W A, Widman M, Lindgren J E, Agurell S

出版信息

J Pharm Pharmacol. 1977 Aug;29(8):487-90. doi: 10.1111/j.2042-7158.1977.tb11374.x.

DOI:10.1111/j.2042-7158.1977.tb11374.x

PMID:19598

Abstract

The in vivo transformation of cannabinol (CBN) in the rat has been studied. Unchanged CBN and nine neutral mono-oxygenated and dioxygenated CBN metabolites have been identified. In the mono-oxygenated series the metabolites occurred in decreasing order of prominence as follows: 7-hydroxy-CBN, 4''-hydroxy-CBN, 1''-hydroxy-CBN, 2''-hydroxy-CBN, 3''-hydroxy-CBN, 5''-hydroxy-CBN and CBN-7-al. In the dihydroxylated metabolite series only 1'',7-dihydroxy-CBN and 4'',7-dihydroxy-CBN were found with the former as the more prominent metabolite.

摘要

已对大鼠体内大麻酚（CBN）的转化进行了研究。已鉴定出未变化的CBN以及九种中性单加氧和双加氧CBN代谢物。在单加氧系列中，代谢物按突出程度递减顺序如下：7-羟基-CBN、4''-羟基-CBN、1''-羟基-CBN、2''-羟基-CBN、3''-羟基-CBN、5''-羟基-CBN和CBN-7-醛。在二羟基化代谢物系列中，仅发现了1'',7-二羟基-CBN和4'',7-二羟基-CBN，前者是更突出的代谢物。