Goldberg R A, Holds J B, Ebrahimpour J
Jules Stein Eye Institute, UCLA School of Medicine 90024-7006.
Ophthalmology. 1992 May;99(5):831-6. doi: 10.1016/s0161-6420(92)31920-7.
Six patients with complications of primary or secondary hydroxyapatite implants were studied. Complications included socket infection and/or conjunctival dehiscence. Complications were detected during regular follow-up examinations, and various treatment approaches were used. The hydroxyapatite implant exposure occurred 4 to 6 weeks (mean, 4.5 weeks) after implantation. Three of the six implants were wrapped in preserved donor sclera before implantation. One of the implants showed wide exposure and chronic infection and was removed. In two cases, scleral patch grafts with a conjunctival pedicle graft were performed, resulting in successful coverage of the implant without further conjunctival dehiscence. In one of the patients, a Tenon's conjunctival flap was advanced to cover the defect, and was unsuccessful with the spicules of the hydroxyapatite eroding through the vascular flap after 1 month. Three of the patients demonstrate a persistent conjunctival epithelial defect. These three patients with chronically exposed hydroxyapatite have remained stable with follow-up intervals ranging from 8 to 12 months. Early exposure of hydroxyapatite orbital implants is a potential problem despite meticulous technique. Implant coverage is difficult, although chronic exposure seems to be tolerated often in the hydroxyapatite orbital implant without migration or extrusion.
对6例原发性或继发性羟基磷灰石植入物出现并发症的患者进行了研究。并发症包括眼窝感染和/或结膜裂开。并发症在定期随访检查中被发现,并采用了各种治疗方法。羟基磷灰石植入物暴露发生在植入后4至6周(平均4.5周)。6枚植入物中有3枚在植入前用保存的供体巩膜包裹。其中1枚植入物出现广泛暴露和慢性感染,被取出。2例患者进行了带结膜蒂移植物的巩膜补片移植,成功覆盖了植入物,未再出现结膜裂开。1例患者推进了提上睑肌结膜瓣以覆盖缺损,但1个月后羟基磷灰石微粒侵蚀穿过血管瓣,手术失败。3例患者存在持续性结膜上皮缺损。这3例羟基磷灰石长期暴露的患者在8至12个月的随访期间病情保持稳定。尽管技术精细,但羟基磷灰石眼眶植入物的早期暴露仍是一个潜在问题。植入物的覆盖很困难,不过在羟基磷灰石眼眶植入物中,慢性暴露似乎常常能被耐受,不会发生移位或挤出。