Huovinen K J, Lähteenmäki P, Kärkkäinen J, Tikkanen M J
Rinnekoti Institute for the Mentally Retarded, University of Helsinki, Finland.
Acta Obstet Gynecol Scand. 1992 Apr;71(3):175-80. doi: 10.3109/00016349209009914.
The effect of reducing the dose of peroral lynestrenol by half on serum sex-hormone, lipid and lipoprotein status was studied in 21 mentally retarded women with therapeutic amenorrhea (TA). They had previously received 5 or 10 mg peroral lynestrenol daily for periods ranging from 32 to 196 months. Dose halving of lynestrenol resulted in an increase in serum total testosterone (T) by 16% (p less than 0.05), sex-hormone binding globulin (SHBG) by 39% (p less than 0.01) and high-density lipoprotein cholesterol (HDL-C) by 28% (p less than 0.001). Both the mean serum total and free concentrations of norethisterone (NET and fNET) decreased by 60% (p less than 0.001). The serum concentrations of 17-beta-estradiol (E2), its free fractions (fE2) and free T (fT) were not significantly altered. Significant correlations were observed between the change in HDL-C and the change in T (r = 0.45, p less than 0.05), between the change in SHBG and the change in T (r = 0.62, p less than 0.01), fT (r = 0.43, p less than 0.05) and E2 (r = 0.51, p less than 0.05). The elevation of HDL-C was probably caused by the reduced serum NET concentrations. This also resulted in an increase in serum SHBG concentration, which is regarded as an indicator of the overall estrogen/androgen ratio.
对21名患有治疗性闭经（TA）的智障女性，研究了口服炔雌醇剂量减半对血清性激素、脂质和脂蛋白状况的影响。她们此前每日口服5或10毫克炔雌醇，时间为32至196个月。炔雌醇剂量减半导致血清总睾酮（T）增加16%（p<0.05），性激素结合球蛋白（SHBG）增加39%（p<0.01），高密度脂蛋白胆固醇（HDL-C）增加28%（p<0.001）。炔诺酮（NET）和游离炔诺酮（fNET）的血清总浓度和游离浓度均值均下降60%（p<0.001）。17-β-雌二醇（E2）及其游离部分（fE2）和游离睾酮（fT）的血清浓度无显著变化。观察到HDL-C变化与T变化之间存在显著相关性（r = 0.45，p<0.05），SHBG变化与T变化（r = 0.62，p<0.01）、fT（r = 0.43，p<0.05）和E2（r = 0.51，p<0.05）之间存在显著相关性。HDL-C升高可能是由于血清NET浓度降低所致。这也导致血清SHBG浓度升高，SHBG被视为整体雌激素/雄激素比例的指标。
