Huovinen K, Tikkanen M J, Autio S, Härkönen T, Lommi L, Varonen S, Wilska M L
Rinnekoti Institute for the Mentally Retarded, Espoo, Finland.
Acta Obstet Gynecol Scand. 1991;70(4-5):349-54. doi: 10.3109/00016349109007886.
Serum concentrations of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), apolipoprotein A1 (Apo A1), and apolipoprotein B (Apo B) were determined in mentally handicapped subjects (n = 87). 33 women were on lynestrenol 5-10 mg for therapeutic amenorrhea (TA). 18 of them were randomly allocated to continue on lynestrenol and 15 were switched to intramuscular administration of medroxyprogesterone (DMPA). The switch to DMPA resulted in significant increases in HDL-C (33%), Apo A1 (12%), as well as in the HDL-C/LDL-C (48%) and Apo A1/Apo B (22%) ratios. The concentrations of HDL-C and Apo A1 were significantly greater in patients receiving DMPA, than in patients continuing with lynestrenol therapy. The amenorrhea incidence, however, did not differ between the two therapy groups. It is concluded that therapy with DMPA may be associated with smaller atherosclerosis risk than with peroral lynestrenol, because of its weaker effect on HDL-C and A1 levels.
测定了87名智力障碍受试者的血清总胆固醇、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、载脂蛋白A1（Apo A1）和载脂蛋白B（Apo B）浓度。33名女性因治疗性闭经（TA）服用炔雌醇5 - 10毫克。其中18人被随机分配继续服用炔雌醇，15人改为肌肉注射甲羟孕酮（DMPA）。改用DMPA后，HDL-C（33%）、Apo A1（12%）以及HDL-C/LDL-C比值（48%）和Apo A1/Apo B比值（22%）显著升高。接受DMPA治疗的患者中HDL-C和Apo A1的浓度显著高于继续接受炔雌醇治疗的患者。然而，两个治疗组的闭经发生率没有差异。结论是，由于DMPA对HDL-C和A1水平的影响较弱，与口服炔雌醇相比，DMPA治疗可能与较小的动脉粥样硬化风险相关。
