Astrup A, Breum L, Toubro S, Hein P, Quaade F
Research Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Copenhagen, Denmark.
Int J Obes Relat Metab Disord. 1992 Apr;16(4):269-77.
The sympathomimetic agent ephedrine has potent thermogenic and anti-obesity properties in rodents. The effect is markedly enhanced by caffeine, while caffeine given alone has no effect. This study was undertaken to find out if a similar weight reducing synergism between ephedrine and caffeine is present in obese patients. In a randomized, placebo-controlled, double blind study, 180 obese patients were treated by diet (4.2 MJ/day) and either an ephedrine/caffeine combination (20mg/200mg), ephedrine (20 mg), caffeine (200 mg) or placebo three times a day for 24 weeks. Withdrawals were distributed equally in the four groups, and 141 patients completed the trial. Mean weight losses was significantly greater with the combination than with placebo from week 8 to week 24 (ephedrine/caffeine, 16.6 +/- 6.8 kg vs. placebo, 13.2 +/- 6.6 kg (mean +/- s.d.), P = 0.0015). Weight loss in both the ephedrine and the caffeine groups was similar to that of the placebo group. Side effects (tremor, insomnia and dizziness) were transient and after eight weeks of treatment they had reached placebo levels. Systolic and diastolic blood pressure fell similarly in all four groups. We conclude, that in analogy with animal studies, the ephedrine/caffeine combination is effective, while caffeine and ephedrine separately are ineffective for the treatment of human obesity.
拟交感神经药麻黄碱在啮齿动物中具有强大的产热和抗肥胖特性。咖啡因可显著增强这种作用，而单独使用咖啡因则没有效果。本研究旨在探究麻黄碱和咖啡因之间类似的减肥协同作用在肥胖患者中是否存在。在一项随机、安慰剂对照、双盲研究中，180名肥胖患者接受饮食治疗（4.2兆焦耳/天），并每天三次服用麻黄碱/咖啡因组合（20毫克/200毫克）、麻黄碱（20毫克）、咖啡因（200毫克）或安慰剂，持续24周。各治疗组的退出人数分布均匀，141名患者完成了试验。从第8周开始至第24周，麻黄碱/咖啡因组合组的平均体重减轻显著大于安慰剂组（麻黄碱/咖啡因组，16.6±6.8千克，安慰剂组，13.2±6.6千克（平均值±标准差），P = 0.0015）。麻黄碱组和咖啡因组的体重减轻与安慰剂组相似。副作用（震颤、失眠和头晕）是短暂的，治疗八周后副作用发生率降至安慰剂组水平。所有四组的收缩压和舒张压下降情况相似。我们得出结论，与动物研究类似，麻黄碱/咖啡因组合对治疗人类肥胖有效，而单独使用咖啡因和麻黄碱则无效。
