Boertje S B, Ward S, Robinson A
Department of Biology, Southern University at New Orleans, Louisiana 70126.
Res Commun Chem Pathol Pharmacol. 1992 May;76(2):143-54.
Earlier investigations suggested that histamine H2-receptors mediate alterations in cerebrovascular permeability in mammals. The objective of this study was to observe the effects of the H2-receptor antagonist ranitidine on histamine-stimulated alterations in the permeability of the blood-brain barrier (BBB) of rats. Normotensive Wistar-Kyoto (WKY) (control) and spontaneously hypertensive (SHR) rats were premedicated with ranitidine (1 mg/kg), followed by histamine (1.25, 2.5 or 5.0 micrograms/kg) or saline. Animals were anesthetized and permeability of the BBB was evaluated with 99mTc-labeled sodium pertechnetate (TcO4-) or with 131I-labeled human serum albumin (RISA). In both control and hypertensive rats, ranitidine blocked histamine-induced changes in cerebrovascular permeability, but did not inhibit histamine-stimulated systemic hypotension. The alterations in the permeability of the BBB did not correlate with variations in blood pressure produced by histamine.
早期研究表明，组胺H2受体介导哺乳动物脑血管通透性的改变。本研究的目的是观察H2受体拮抗剂雷尼替丁对组胺刺激的大鼠血脑屏障（BBB）通透性改变的影响。对血压正常的Wistar-Kyoto（WKY）（对照）大鼠和自发性高血压（SHR）大鼠预先给予雷尼替丁（1mg/kg），随后给予组胺（1.25、2.5或5.0μg/kg）或生理盐水。动物麻醉后，用99mTc标记的高锝酸钠（TcO4-）或131I标记的人血清白蛋白（RISA）评估血脑屏障的通透性。在对照大鼠和高血压大鼠中，雷尼替丁均能阻断组胺诱导的脑血管通透性变化，但不抑制组胺刺激引起的全身低血压。血脑屏障通透性的改变与组胺引起的血压变化无关。
