Domer F R, Boertje S B, Sweeney S A
Res Commun Chem Pathol Pharmacol. 1983 Oct;42(1):157-60.
We have studied the effects of premedication with either atropine or pyrilamine on the responses of the blood pressure and the permeability of the blood-brain barrier (BBB) in normotensive (WKY) or spontaneously hypertensive (SHR) rats given acetylcholine or histamine. The rats were anesthetized with pentobarbital and the permeability of the BBB evaluated by the extravasation of either 131I-labeled radioiodinated serum albumin (RISA) or 99Tc-labeled sodium pertechnetate (TcO-4). Premedication greatly diminished the hypotensive responses to both acetylcholine and histamine, especially in the SHR animals. Additionally, the premedication blocked the increased permeability of the BBB, especially in SHR rats given TcO-4. The hypotension caused by acetylcholine or histamine in these premedicated animals given RISA again emphasizes the lack of predictability of changes in blood pressure and the permeability of the BBB.
我们研究了在给予乙酰胆碱或组胺的正常血压（WKY）大鼠或自发性高血压（SHR）大鼠中，预先使用阿托品或吡苄明对血压反应及血脑屏障（BBB）通透性的影响。大鼠用戊巴比妥麻醉，通过131I标记的放射性碘化血清白蛋白（RISA）或99Tc标记的高锝酸钠（TcO-4）外渗来评估BBB的通透性。预先用药大大减弱了对乙酰胆碱和组胺的降压反应，尤其是在SHR动物中。此外，预先用药阻断了BBB通透性的增加，尤其是在给予TcO-4的SHR大鼠中。在这些给予RISA的预先用药动物中，由乙酰胆碱或组胺引起的低血压再次强调了血压变化和BBB通透性缺乏可预测性。
