Slichenmyer W J, LeMaistre C F, Von Hoff D D
Department of Medicine, University of Texas Health Science Center, San Antonio.
Invest New Drugs. 1992 Apr;10(1):45-8. doi: 10.1007/BF01275481.
Two patients with metastatic spread of unusual tumors responded to treatment with high-dose Melphalan and autologous bone marrow transplant. One patient had adenoid cystic carcinoma of a minor salivary gland and the other had Merkel cell tumor of the scalp. Both patients had undergone prior surgery and radiotherapy, but later relapsed with distant metastases. Both patients had progression of their disease despite conventional and salvage chemotherapy. Treatment with high-dose Melphalan and autologous bone marrow transplant resulted in partial responses for both patients. High-dose Melphalan should be considered for therapy earlier in the course of patients with these unusual cancers.
两名患有罕见肿瘤转移扩散的患者对大剂量美法仑和自体骨髓移植治疗有反应。一名患者患有小唾液腺腺样囊性癌，另一名患者患有头皮默克尔细胞瘤。两名患者均曾接受过手术和放疗，但后来出现远处转移复发。尽管接受了传统和挽救性化疗，两名患者的病情仍有进展。大剂量美法仑和自体骨髓移植治疗使两名患者均出现部分缓解。对于患有这些罕见癌症的患者，在病程早期就应考虑使用大剂量美法仑进行治疗。
