Wynne C J, Kearsley J H
Queensland Radium Institute, Herston, Australia.
Cancer. 1988 Jul 1;62(1):28-31. doi: 10.1002/1097-0142(19880701)62:1<28::aid-cncr2820620107>3.0.co;2-j.
The clinical courses of six patients treated with cytotoxic chemotherapy for recurrent Merkel cell tumor of the skin are reported. All patients experienced prompt clinical responses to chemotherapy (five complete response [CR], one partial response [PR]) and three patients (50%) have achieved long-term disease-free remission. The report highlights (1) the aggressive nature of Merkel cell skin cancer, (2) the highly chemosensitive nature of the disease, and (3) some practical problems in administering chemotherapy to elderly patients.
报告了6例接受细胞毒性化疗治疗复发性皮肤默克尔细胞癌患者的临床病程。所有患者对化疗均迅速产生临床反应（5例完全缓解[CR]，1例部分缓解[PR]），3例患者（50%）实现了长期无病缓解。该报告强调了（1）默克尔细胞皮肤癌的侵袭性，（2）该疾病对化疗高度敏感的性质，以及（3）在老年患者中进行化疗时的一些实际问题。
