[心脏直视手术后血管紧张素转换酶指数升高]

[Angiotensin converting enzyme index increases after open cardiac surgery].

作者信息

Kayaba M, Enzan K, Suzuki M

机构信息

Department of Anesthesiology, Akita University School of Medicine.

出版信息

Masui. 1992 May;41(5):822-4.

PMID:1318980

Abstract

To investigate whether pulmonary endothelial cells are damaged after open cardiac, open chest, or head-neck surgery, we measured angiotensin converting enzyme (ACE) and calculated ACE index (ACE.cardiac output-1) to exclude the influence of pulmonary perfusion volume in 38 patients. There were no significant differences among three groups in serum ACE (9.93 +/- 2.46 IU.l-1 after open cardiac surgery, 8.50 +/- 2.75 IU.l-1 after open chest surgery, 10.71 +/- 2.23 IU.l-1 after head-neck surgery). ACE index after open cardiac surgery was significantly higher than those after open chest and head-neck surgery (2.43 +/- 0.85, 1.67 +/- 0.69, 1.64 +/- 0.50 respectively). These results suggest that ACE index detects pulmonary endothelial cell damage caused by reperfusion after cardiopulmonary bypass. We conclude that ACE index is more useful than ACE as an early clinical marker of pulmonary endothelial cell damage.

摘要

为了研究在心脏直视手术、开胸手术或头颈手术后肺内皮细胞是否受损，我们测量了38例患者的血管紧张素转换酶（ACE）并计算了ACE指数（ACE·心输出量⁻¹），以排除肺灌注量的影响。三组患者的血清ACE无显著差异（心脏直视手术后为9.93±2.46 IU·l⁻¹，开胸手术后为8.50±2.75 IU·l⁻¹，头颈手术后为10.71±2.23 IU·l⁻¹）。心脏直视手术后的ACE指数显著高于开胸手术和头颈手术后的ACE指数（分别为2.43±0.85、1.67±0.69、1.64±0.50）。这些结果表明，ACE指数可检测体外循环后再灌注引起的肺内皮细胞损伤。我们得出结论，作为肺内皮细胞损伤的早期临床标志物，ACE指数比ACE更有用。