Barach J P, Wikswo J P
Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee 37235.
Comput Biomed Res. 1992 Jun;25(3):212-7. doi: 10.1016/0010-4809(92)90039-d.
Numerical simulations of a propagating cardiac action potential utilizing Beeler-Reuter and Drouhard-Roberge physiological routines for the membrane current have been performed. These action potentials show increases in action potential duration when subjected to strong late stimuli of either positive or negative polarity. The mechanism is the same as that reported in an earlier paper which utilized a different physiological approach: repolarizing stimuli can reset the fast sodium gates locally so that they can be retriggered by diffusive return of charge from surrounding tissue. This results in a large depolarizing transient that lengthens action potential duration.
利用Beeler-Reuter和Drouhard-Roberge膜电流生理程序对传播的心脏动作电位进行了数值模拟。当受到强的正极性或负极性晚期刺激时，这些动作电位的动作电位时程会增加。其机制与早期一篇采用不同生理学方法的论文中报道的相同：复极化刺激可局部重置快速钠通道，使其能够被周围组织电荷的扩散回流重新触发。这会导致一个大的去极化瞬变，从而延长动作电位时程。
