Zheng F, Gallagher J P
Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77550.
Eur J Pharmacol. 1992 Feb 11;211(2):281-2. doi: 10.1016/0014-2999(92)90542-c.
We have demonstrated that burst firing in rat dorsolateral septal nucleus neurons is a specific response following activation of metabotropic glutamate receptors. Now we report that the burst firing induced by 1S,3R-ACPD (1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid), a selective agonist, is blocked by inorganic calcium channel blockers. Our data suggest that influx of external calcium is required for this metabotropic glutamate response. Intracellular second messenger pathways coupled to the metabotropic glutamate receptor may be more complex than releasing calcium from IP3-sensitive internal stores as is currently hypothesized.
我们已经证明，大鼠背外侧隔核神经元的爆发式放电是代谢型谷氨酸受体激活后的一种特异性反应。现在我们报告，选择性激动剂1S,3R-ACPD（1S,3R-1-氨基环戊烷-1,3-二羧酸）诱导的爆发式放电被无机钙通道阻滞剂阻断。我们的数据表明，这种代谢型谷氨酸反应需要细胞外钙的内流。与代谢型谷氨酸受体偶联的细胞内第二信使途径可能比目前所假设的从IP3敏感的内部储存库释放钙更为复杂。
