[Activity of the hypophyseal-adrenal system under the influence of substances of mediator type action].

The paper treats of the results indicating the activation of the hypophysioadrenal system following the stimulation of the central adreno-, cholino-, serotonino- and histamino-sensitive receptors in case of administration of the mediators or their precursors into the third ventricle of the rat brain. At the same time it was shown that depression of catecholamine and serotonin synthesis in the brain after the administration of alpha-methylparatyrosine or parachlorphenylalanine, respectively, and also an exhaustion of the tissue stores of the monoamines in administration of reserpine failed to influence significantly the reaction of the hypophysio-adrenal system to the immobilization of the animals. The data obtained led to the conclusion that the reactions of the hypothalamus-hypophysis-adrenal cortex system to the stimuli were not strictly determined by any one monoaminergic mechanism of the brain.