Popova N K, Lobacheva I I
Ontogenez. 1981;12(4):382-9.
The concentration of corticosteroids in the blood of rats was shown to increase in response to the immobilization stress at an earlier age than the brain serotonin metabolism changes. The level of corticosteroids in blood increased in response to the intraperitoneal serotonin injection also earlier than the reaction to the serotonin injection in the brain lateral ventricle sets up. The increase of the reaction of hypophysial-suprarenal system to stress during the period from the 12th till the 16th day of postnatal development coincided with the changes in serotonin metabolism in the brain stem and the reaction to serotonin injection in the brain lateral ventricle. It is suggested that the system of serotonin brain neurons connected with the hypophysial-suprarenal complex matures later tran the serotonin receptors in the periphery; the reaction to immobilization may be realized at the early developmental stages without the participation of brain serotonin.
研究表明，大鼠血液中皮质类固醇的浓度在比脑血清素代谢变化更早的年龄就因固定应激而增加。腹腔注射血清素时，血液中皮质类固醇水平的升高也早于脑侧脑室注射血清素时的反应。出生后第12天至第16天期间，垂体 - 肾上腺系统对应激反应的增强与脑干血清素代谢的变化以及脑侧脑室注射血清素的反应相吻合。有人提出，与垂体 - 肾上腺复合体相连的脑血清素神经元系统比外周的血清素受体成熟得晚；固定反应可能在发育早期阶段就可实现，而无需脑血清素的参与。
