Vertogradova O P, Misionzhinik E Iu, Poliakov S E, Uzbekov M G
Zh Nevropatol Psikhiatr Im S S Korsakova. 1992;92(1):99-103.
The purpose of the work was to specify the possibilities of the use of the enzymes of mediator metabolism: monoamine oxidase (MAO) of platelets, amine oxidase (AO) of serum and acetyl cholinesterase (ACE) of red blood cells to estimate the structure of depressions and to predict their therapeutic dynamics. 32 patients in the depressive phase of MDP were examined. There were 28 women and 4 men aged 22 to 50 years. The monopolar type was recorded in 28 patients, the bipolar one in 4 (all women). The total disease duration amounts to 0.5-17 years; depression may last from 2 months to 4 years. Depending on the type of the dominant affect the patients were distributed into 2 groups (10 persons had melancholic and 22 anxious depression). It has been shown that activity of platelet MAO and serum AO was significantly higher in anxious than in melancholic depression. An interrelationship was established between activity of these enzymes before treatment and prognosis of the treatment with tricyclic antidepressants. Activation of the enzymes during therapy was parallelled by positive clinical changes. Activity of platelet MAO turned out most significant in terms of prognosis. The data obtained are analyzed from the standpoint of regarding depression as a stressful condition, with the participation of the neurohormonal axis: the hypothalamus, pituitary, and adrenal cortex.
血小板单胺氧化酶（MAO）、血清胺氧化酶（AO）和红细胞乙酰胆碱酯酶（ACE）来评估抑郁症的结构并预测其治疗动态。对32例处于躁郁症抑郁期的患者进行了检查。其中有28名女性和4名男性，年龄在22至50岁之间。28例患者为单相型，4例（均为女性）为双相型。疾病总病程为0.5至17年；抑郁可能持续2个月至4年。根据主导情感类型，患者被分为2组（10例为 melancholic 抑郁，22例为焦虑性抑郁）。结果表明，焦虑性抑郁患者血小板MAO和血清AO的活性显著高于 melancholic 抑郁患者。这些酶治疗前的活性与三环类抗抑郁药治疗的预后之间建立了相互关系。治疗期间酶的激活与临床积极变化平行。就预后而言，血小板MAO的活性最为显著。从将抑郁症视为一种应激状态的角度，结合神经激素轴（下丘脑、垂体和肾上腺皮质）的参与，对所获得的数据进行了分析。
