Walters J D, Sorboro D M, Chapman K J
Department of Periodontology, College of Dentistry, Ohio State University, Columbus 43210.
FEBS Lett. 1992 Jun 8;304(1):37-40. doi: 10.1016/0014-5793(92)80584-4.
Spermidine and putrescine (50 microM-1 mM), found in exudates from infection sites, significantly enhance fMet-Leu-Phe-induced Ca2+ mobilization in differentiated HL-60 cells and polymorphonuclear leukocytes (PMNs) by delaying the return to basal cytosolic Ca2+ levels. This enhancement by polyamines is associated with inhibition of Ca2+ efflux across the plasma membrane. In parallel with their effects on Ca2+ signaling, polyamines also significantly prolong the kinetics of fMet-Leu-Phe-induced protein kinase C translocation. Thus, polyamines may play a novel role in modulating regulatory events in phagocytes.
在感染部位的渗出物中发现的亚精胺和腐胺（50微摩尔-1毫摩尔），通过延迟细胞溶质钙水平恢复到基础水平，显著增强了fMet-Leu-Phe诱导的分化HL-60细胞和多形核白细胞（PMN）中的钙动员。多胺的这种增强作用与抑制钙通过质膜的外流有关。与它们对钙信号传导的影响并行，多胺还显著延长了fMet-Leu-Phe诱导的蛋白激酶C转位的动力学。因此，多胺可能在调节吞噬细胞中的调节事件中发挥新的作用。
