Walters J D, Chapman K J
Department of Periodontology, College of Dentistry, Ohio State University, Columbus 43210, USA.
J Periodontal Res. 1995 May;30(3):167-71. doi: 10.1111/j.1600-0765.1995.tb01269.x.
Many bacterial and host cells contain large amounts of polyamines that can be released at infection sites as a result of cell lysis. Consequently, the putrescine and spermidine content of gingival fluid from inflamed periodontal pockets (0.1 to 1 mM) is sharply elevated in comparison to peripheral blood. At these levels, polyamines potentiated fMet-Leu-Phe-induced Ca2+ signaling in polymorphonuclear leukocytes (PMNs) in vitro. Consistent with the essential role of Ca2+ signaling in PMN activation, secondary granule release and superoxide anion production by fMet-Leu-Phe-stimulated PMNs was enhanced in the presence of polyamines. Thus, polyamines may play a local role in modulating the antimicrobial activity of PMNs in periodontal disease.
许多细菌和宿主细胞含有大量的多胺，细胞裂解时这些多胺可在感染部位释放。因此，与外周血相比，来自发炎牙周袋的龈沟液中腐胺和亚精胺含量（0.1至1 mM）急剧升高。在这些浓度下，多胺在体外增强了甲酰甲硫氨酸-亮氨酸-苯丙氨酸（fMet-Leu-Phe）诱导的多形核白细胞（PMN）中的Ca2+信号传导。与Ca2+信号传导在PMN激活中的重要作用一致，在多胺存在下，fMet-Leu-Phe刺激的PMN的次级颗粒释放和超氧阴离子产生增强。因此，多胺可能在调节牙周疾病中PMN的抗菌活性方面发挥局部作用。
