维生素E的辐射防护作用：单独注射维生素E或与WR-3689联合注射可提高受辐照小鼠的存活率。

Radioprotection by vitamin E: injectable vitamin E administered alone or with WR-3689 enhances survival of irradiated mice.

作者信息

Srinivasan V, Weiss J F

机构信息

Radiation Biochemistry Department, Armed Forces Radiobiology Research Institute, Bethesda, MD 20889-5145.

出版信息

Int J Radiat Oncol Biol Phys. 1992;23(4):841-5. doi: 10.1016/0360-3016(92)90657-4.

DOI:10.1016/0360-3016(92)90657-4

PMID:1319980

Abstract

Radioprotection by injectable vitamin E (alpha-tocopherol) was investigated in mice exposed to 60Co radiation (0.2 Gy/min). Vitamin E injected subcutaneously either 1 hr before or within 15 min after irradiation significantly increased 30-day postirradiation survival in CD2F1 male mice. A dose reduction factor (DRF) of 1.11 (95% confidence interval [1.08, 1.14]) was observed for vitamin E at a dose of 100 IU/kg body weight administered within 15 min after irradiation. Combination studies with the phosphorothioate WR-3689 (S-2([3-methylaminopropyl]amino)ethylphosphorothioic acid) were undertaken to determine whether radioprotection by WR-3689 could be enhanced by vitamin E. Mice were given WR-3689 (150-225 mg/kg, intraperitoneally) 30 min before irradiation and were given vitamin E (100 IU/kg) either 1 hr before or within 15 min after irradiation. Survival was significantly increased in mice given vitamin E and WR-3689 before irradiation as compared to mice given WR-3689 alone: the DRF for WR-3689 (150 mg) was 1.35 [1.32, 1.38]; for WR-3689 combined with vitamin E (100 IU), the DRF was 1.49 [1.45, 1.53].

摘要

研究了注射用维生素E（α-生育酚）对受60Co辐射（0.2 Gy/分钟）的小鼠的辐射防护作用。在照射前1小时或照射后15分钟内皮下注射维生素E，可显著提高CD2F1雄性小鼠照射后30天的存活率。照射后15分钟内给予100 IU/千克体重的维生素E，剂量降低因子（DRF）为1.11（95%置信区间[1.08, 1.14]）。进行了与硫代磷酸酯WR-3689（S-2([3-甲氨基丙基]氨基)乙硫代磷酸）的联合研究，以确定维生素E是否能增强WR-3689的辐射防护作用。小鼠在照射前30分钟腹腔注射WR-3689（150 - 225毫克/千克），并在照射前1小时或照射后15分钟内给予维生素E（100 IU/千克）。与单独给予WR-3689的小鼠相比，照射前给予维生素E和WR-3689的小鼠存活率显著提高：WR-3689（150毫克）的DRF为1.35 [1.32, 1.38]；WR-3689与维生素E（100 IU）联合使用时，DRF为1.49 [1.45, 1.53]。