MSH/促肾上腺皮质激素类似物ORG 2766在焦虑症中的作用

The MSH/ACTH analog ORG 2766 in anxiety disorders.

作者信息

Den Boer J A, Westenberg H G, De Vries H

机构信息

Department of Biological Psychiatry, University Hospital Utrecht, The Netherlands.

出版信息

Peptides. 1992 Jan-Feb;13(1):109-12. doi: 10.1016/0196-9781(92)90147-u.

DOI:10.1016/0196-9781(92)90147-u

PMID:1320259

Abstract

The anxiolytic effects of the MSH/ACTH analog ORG 2766 were assessed in three different groups of patients with an anxiety disorder: panic disorder, generalized anxiety and social phobia. Patients were treated with capsules containing 20 mg ORG 2766 or placebo and received 4 capsules daily for six weeks. A slight reduction on the Hamilton Anxiety Scale was found after ORG 2766 treatment in the panic disorder patients, while the peptide did not affect the number of panic attacks in these patients. In the other two patient groups no anxiolytic effect of ORG 2766 was observed.

摘要

在三组不同的焦虑症患者（惊恐障碍、广泛性焦虑症和社交恐惧症）中评估了促黑素/促肾上腺皮质激素类似物ORG 2766的抗焦虑作用。患者接受含有20毫克ORG 2766的胶囊或安慰剂治疗，每天服用4粒胶囊，持续六周。在惊恐障碍患者中，ORG 2766治疗后汉密尔顿焦虑量表评分略有降低，而该肽对这些患者的惊恐发作次数没有影响。在其他两组患者中未观察到ORG 2766的抗焦虑作用。