Charuvanij A, Ouvrier R A, Procopis P G, Antony J H, Fagan E R
Department of Neurology, Royal Alexandra Hospital for Children, Camperdown NSW, Sydney.
Brain Dev. 1992 Mar;14(2):102-6. doi: 10.1016/s0387-7604(12)80095-7.
Between 1980 and 1989, 21 children suffering from intractable seizures other than infantile spasms were treated with intramuscular ACTH at the Children's Hospital Camperdown. Five patients had two courses of ACTH therapy, 24% of patients had a good response (group A), 56% responded transiently (group B) and 20% did not respond (group C). Group A had normal development and no neurological deficits prior to seizures. A favourable response was not observed in patients with partial seizures, 90% of the patients who responded had a recurrence of seizures. Mean time to recurrence was 9.0 +/- 7.3 months in group A and 1.6 +/- 2.0 months in group B. Hypokalaemia, hypertension and infection were found in 42.9%, 33.3% and 19.1% respectively. ACTH also had effects on concurrent anti-epileptic drug levels.
1980年至1989年间，坎珀当儿童医院对21名患有除婴儿痉挛症以外的顽固性癫痫发作的儿童进行了肌肉注射促肾上腺皮质激素（ACTH）治疗。5名患者接受了两个疗程的ACTH治疗，24%的患者反应良好（A组），56%的患者有短暂反应（B组），20%的患者无反应（C组）。A组患者在癫痫发作前发育正常且无神经功能缺损。部分性癫痫患者未观察到良好反应，有反应的患者中90%癫痫复发。A组癫痫复发的平均时间为9.0±7.3个月，B组为1.6±2.0个月。低钾血症、高血压和感染的发生率分别为42.9%、33.3%和19.1%。ACTH对同时使用的抗癫痫药物水平也有影响。
