Shanavas K R, Kala V, Vasudevan D M, Vijayakumar T, Yadav M
Department of Biochemistry, Medical College, Trichur, Kerala, India.
J Exp Pathol. 1992;6(1-2):95-105.
The prevalence and titre of IgG antibodies to human herpesvirus type 6 (HHV-6) were assayed in the serum samples from normal subjects and patients with Hodgkin's lymphoma (HL), non-Hodgkin's lymphoma (NHL), acute lymphoblastic leukaemia (ALL) and oral cancer (OC) using immunofluorescence and immunoperoxidase techniques. This forms the first study on the sero-prevalence and titre of antibodies to HHV-6 in India. There was no considerable difference in the prevalence (76%) and titre (10-160) of the antibodies in normal population from those reported for normal adults in other parts of the world. All the HL and ALL patients studied showed no significant elevation in the antibody titre, though a slight increase in the prevalence (95%) was noted. Antibody titre and prevalence were found highly elevated in OC. OC remained totally unstudied for the presence of anti-HHV-6 antibodies, and this is the first report of elevated levels of the antibody in this cancer. The role of HHV-6, if any, in the pathogenesis of OC is worth investigating.
采用免疫荧光和免疫过氧化物酶技术，对正常受试者以及霍奇金淋巴瘤（HL）、非霍奇金淋巴瘤（NHL）、急性淋巴细胞白血病（ALL）和口腔癌（OC）患者的血清样本进行检测，以测定人疱疹病毒6型（HHV-6）IgG抗体的患病率和滴度。这是印度关于HHV-6抗体血清患病率和滴度的首次研究。正常人群中抗体的患病率（76%）和滴度（10 - 160）与世界其他地区报道的正常成年人相比，没有显著差异。所有研究的HL和ALL患者抗体滴度均无显著升高，不过患病率略有增加（95%）。在OC中发现抗体滴度和患病率大幅升高。此前完全没有针对OC中抗HHV-6抗体存在情况的研究，这是该癌症中抗体水平升高的首次报道。HHV-6在OC发病机制中的作用（若有）值得研究。
