麦角灵同系物作为催乳素释放的潜在抑制剂。3. 3-苯基哌啶的衍生物
Ergoline congeners as potential inhibitors of prolactin release. 3. Derivatives of 3-phenylpiperidine.
作者信息
Rusterholz D B, Barfknecht C F, Clemens J A
出版信息
J Med Chem. 1977 Jan;20(1):85-8. doi: 10.1021/jm00211a017.
PMID:13217
Abstract
In a continuation of our attempts to elucidate the prolactin release inhibiting pharmacophore within the ergoline structure, we have prepared several derivatives of 3-phenylpiperidine. These congeners have been evaluated for inhibition of prolactin release in vivo and are for the most part inactive.
摘要
在我们继续尝试阐明麦角灵结构中催乳素释放抑制药效基团的过程中，我们制备了几种3-苯基哌啶衍生物。这些同系物已在体内进行了催乳素释放抑制评估，并且大部分没有活性。
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