麦角灵同系物作为催乳素释放的潜在抑制剂。2.

Ergoline congeners as potential inhibitors of prolactin release. 2.

作者信息

Rusterholz D B, Barfknecht C F, Clemens J A

出版信息

J Med Chem. 1976 Jan;19(1):99-102. doi: 10.1021/jm00223a016.

Abstract

In our attempts to elucidate the prolactin release inhibiting pharmacophore within the ergoline structure, we have prepared one indolealkylamine and several 2-aminotetralin derivatives. These congeners have been evaluated for inhibition of prolactin release in vivo. One congener, 5,8-dihydroxy-2-dimethylaminotetralin, and the drug M-7 significantly inhibited prolactin secretion.

摘要

在我们试图阐明麦角灵结构中催乳素释放抑制药效团的过程中，我们制备了一种吲哚烷基胺和几种2-氨基四氢萘衍生物。这些同系物已在体内进行了催乳素释放抑制评估。一种同系物5,8-二羟基-2-二甲基氨基四氢萘和药物M-7显著抑制了催乳素分泌。