Kamei J, Tanihara H, Kasuya Y
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Res Commun Chem Pathol Pharmacol. 1992 Jun;76(3):375-8.
When co-administered intracisternally, the selective delta-opioid agonist [D-Pen2,5]enkephalin (DPDPE), which had no significant effect on the cough reflex, consistently and significantly decreased the antitussive potencies of kappa-receptor agonists, U-50,488H and U-62,066E. The decrease in the antitussive effects of these kappa-receptor agonists caused by DPDPE were prevented by selective delta receptor antagonist, naltrindole. These results suggest that delta receptors may play an inhibitory role in antitussive processes that are mediated by the kappa-receptors.
当脑池内共同给药时，对咳嗽反射无显著影响的选择性δ阿片受体激动剂[D-青霉胺2,5]脑啡肽（DPDPE）持续且显著降低κ受体激动剂U-50,488H和U-62,066E的镇咳效力。选择性δ受体拮抗剂纳曲吲哚可阻止DPDPE引起的这些κ受体激动剂镇咳作用的降低。这些结果表明，δ受体可能在由κ受体介导的镇咳过程中发挥抑制作用。
