Yaeger M J, Koestner A, Marushige K, Marushige Y
Department of Pathology, Michigan State University, East Lansing 48824.
Acta Neuropathol. 1992;83(6):624-9. doi: 10.1007/BF00299412.
The rationale behind the evaluation of natural differentiating agents, such as nerve growth factor (NGF), for reverse transforming potential is based on the theory that such compounds may represent a nontoxic means of controlling tumor growth. Previous in vitro experiments have shown that NGF is capable of retarding growth and of inducing persistent differentiation of neurogenic tumor cell lines. In vivo, NGF is capable of causing a persistent reduction in the number of ethylnitrosourea-induced neurinomas and of increasing survival time following intracerebral implantation of F98 anaplastic glioma cells. In this study, anaplastic glioma and neurinoma implants were treated with NGF to evaluate the reverse transforming potential of NGF in vivo. Results indicate that NGF is capable of causing a significant decrease in the growth rate of subcutaneous T9 (anaplastic glioma) and clone 16 (anaplastic neurinoma) implants. Significantly, NGF treatment was accompanied by adverse effects that were minimal and transient. Continued tumor growth (although greatly retarded) following NGF treatment is an aspect that requires further investigation. However, the results of this study suggest that NGF may prove useful, alone or in combination with other types of therapy, for the treatment of tumors of neurogenic origin.
评估诸如神经生长因子（NGF）等天然分化因子的逆转转化潜能背后的基本原理，是基于这样一种理论，即此类化合物可能代表一种控制肿瘤生长的无毒方法。先前的体外实验表明，NGF能够延缓神经源性肿瘤细胞系的生长并诱导其持续分化。在体内，NGF能够使乙基亚硝基脲诱导的神经鞘瘤数量持续减少，并能延长F98间变性胶质瘤细胞脑内植入后的存活时间。在本研究中，用NGF处理间变性胶质瘤和神经鞘瘤植入物，以评估NGF在体内的逆转转化潜能。结果表明，NGF能够使皮下T9（间变性胶质瘤）和克隆16（间变性神经鞘瘤）植入物的生长速率显著降低。值得注意的是，NGF治疗伴随着轻微且短暂的不良反应。NGF治疗后肿瘤持续生长（尽管生长大大延缓）是一个需要进一步研究的方面。然而，本研究结果表明，NGF可能单独或与其他类型的治疗联合使用，对治疗神经源性肿瘤有用。
