Takeuchi K, Suzuki S, Kako N, Kobayashi M, Takahashi S, Sawada M, Honma T, Iwabuchi S, Fukui K, Koyama K
Hirosaki University School of Medicine, Japan.
Ann Thorac Surg. 1992 Aug;54(2):327-32. doi: 10.1016/0003-4975(92)91394-o.
The mechanism by which prostacyclin acts to prevent in vivo reperfusion injury is still uncertain. This study was therefore undertaken to assess the effect of a stable prostacyclin analogue (OP 41483-alpha-CD [OP]) on oxygen-derived free radicals after heart-lung transplantation. OP was administered to the heart-lung graft through the pulmonary artery for 25 minutes encompassing the reperfusion process. Free radicals were directly measured by electron spin resonance spectroscopy. The radical intensities of pulmonary venous blood were significantly lower in the OP group than in the control group, suggesting that fewer free radicals were generated in the lungs of the OP group. The cardiac and respiratory function were better in the OP group than in the control group. The lung is the primary source of oxygen free radical attack, and the beneficial action of OP on free radical generation is almost exclusively restricted to the lung and does not apply to the heart. This result suggested that OP probably is effective in inhibiting free radical generation from the endothelium.
前列环素预防体内再灌注损伤的机制尚不清楚。因此，本研究旨在评估一种稳定的前列环素类似物（OP 41483-α-CD [OP]）对心肺移植后氧衍生自由基的影响。在包括再灌注过程的25分钟内，通过肺动脉将OP给予心肺移植物。通过电子自旋共振光谱直接测量自由基。OP组肺静脉血的自由基强度显著低于对照组，表明OP组肺中产生的自由基较少。OP组的心脏和呼吸功能优于对照组。肺是氧自由基攻击的主要来源，OP对自由基生成的有益作用几乎完全局限于肺，不适用于心脏。这一结果表明，OP可能有效抑制内皮细胞产生自由基。
