Viljanto J, Raekallio J
Br J Surg. 1976 Jun;63(6):427-30. doi: 10.1002/bjs.1800630603.
After débridement of necrotized and devitalized tissue in deep burns and large traumatic soft tissue defects, the raw surfaces were covered with separate sheets of viscose cellulose sponge (VCS), each moistened by continuous slow infusion of one of the following solutions: (a) 0-9 per cent NaCl; (b) 10 per cent glucose; (c) Rheomacrodex (dextrane hydrolysate in 0-9 per cent NaCl); (d) 7 per cent Levamin (a mixture of essential amino acids and glycin in 5 per cent sorbitol; (e) a combination of two solutions containing amino acids (Le-7402 A) and glucose, electrolytes and vitamins (Le-7402 B). The cellulose sponges were removed or changed 3-7 days later. Macroscopically, histologically and enzyme histochemically, the most active granulation tissue formation was found under the VCS moistened with amino acid solutions, especially when accompanied by glucose and vitamin supplementation. The results strongly suggest that local cellular hyperalimentation of open raw wound surfaces is possible, permitting a new kind of nutritional support in these patients.
在对深度烧伤和大面积创伤性软组织缺损的坏死及失活组织进行清创后，创面用单独的粘胶纤维素海绵（VCS）覆盖，每块海绵通过持续缓慢输注下列溶液之一进行湿润：（a）0.9%氯化钠；（b）10%葡萄糖；（c）低分子右旋糖酐（0.9%氯化钠中的右旋糖酐水解物）；（d）7%左旋氨基酸（必需氨基酸与甘氨酸在5%山梨醇中的混合物）；（e）含氨基酸的两种溶液（Le - 7402 A）与含葡萄糖、电解质和维生素的溶液（Le - 7402 B）的组合。3 - 7天后取出或更换纤维素海绵。在宏观、组织学和酶组织化学方面，发现用氨基酸溶液湿润的VCS下肉芽组织形成最为活跃，尤其是在补充葡萄糖和维生素时。结果有力地表明，对开放性创面进行局部细胞营养支持是可行的，可为这些患者提供一种新型的营养支持。
