巴氏腺腺样囊性癌的细胞遗传学分析。一种女性泌尿生殖道罕见的半恶性肿瘤。

Cytogenetic analysis of an adenoid cystic carcinoma of the Bartholin's gland. A rare, semimalignant tumor of the female genitourinary tract.

作者信息

Kiechle-Schwarz M, Kommoss F, Schmidt J, Lukovic L, Walz L, Bauknecht T, Pfleiderer A

机构信息

Department of Gynecology and Obstetrics, Albert-Ludwigs University, Freiburg, Germany.

出版信息

Cancer Genet Cytogenet. 1992 Jul 1;61(1):26-30. doi: 10.1016/0165-4608(92)90365-f.

DOI:10.1016/0165-4608(92)90365-f

PMID:1322232

Abstract

Cytogenetic analysis has been performed on short-term cultures from a 56-year-old woman suffering from an adenoid cystic carcinoma of Bartholin's gland. Beside a normal female karyotype, the tumor revealed an abnormal cell line with complex chromosome changes involving the chromosomes 1, 4, 6, 11, 22, and 14. The mainly structural and nonbalanced rearrangements led to the loss of the chromosome segments 1p31----qter, 4q22----q28, 6p12----qter, 11p11.2----pter, 14q24----qter, and 22q13----qter. Clonal numerical aberrations were not observed. To our knowledge, such a tumor has to-date not been cytogenetically investigated.

摘要

对一名患有巴氏腺腺样囊性癌的56岁女性的短期培养细胞进行了细胞遗传学分析。除了正常的女性核型外，肿瘤还显示出一条异常细胞系，其染色体发生了复杂变化，涉及1号、4号、6号、11号、22号和14号染色体。主要的结构和非平衡性重排导致了1p31----qter、4q22----q28、6p12----qter、11p11.2----pter、14q24----qter和22q13----qter染色体片段的缺失。未观察到克隆性数目畸变。据我们所知，迄今为止尚未对这种肿瘤进行细胞遗传学研究。