Koide S, Onishi H, Yamagami S, Kawakita Y
Department of Neuropsychiatry, Osaka City University Medical School, Japan.
Neurochem Res. 1992 Aug;17(8):779-83. doi: 10.1007/BF00969012.
Opioid agonists were used to investigate the modulation of seizures in the seizure-susceptible El mouse. Morphine and D-Ala2-D-Leu5-enkephalin (DADLE) were injected subcutaneously or intracisternally as prototypic agonists for mu and delta opioid receptors. Systemic or intracisternal injection of both morphine and DADLE decreased the incidence of seizures and the seizure score in El mice in a dose-dependent manner. The anticonvulsant effects of morphine and DADLE were reversed by naloxone (2 mg/kg, s.c.). This implies that opioid agonists have anticonvulsant properties which are mediated by mu and delta opioid receptors. In conclusion, a deficit in endogenous opioid peptides, which act as anticonvulsants may play a significant role in the etiology or pathophysiology of seizures in the El mouse.
使用阿片类激动剂研究癫痫易感的El小鼠中癫痫发作的调节情况。吗啡和D - 丙氨酸2 - D - 亮氨酸5 - 脑啡肽（DADLE）作为μ和δ阿片受体的典型激动剂进行皮下或脑池内注射。吗啡和DADLE的全身或脑池内注射均以剂量依赖性方式降低了El小鼠的癫痫发作发生率和癫痫发作评分。纳洛酮（2mg/kg，皮下注射）可逆转吗啡和DADLE的抗惊厥作用。这表明阿片类激动剂具有由μ和δ阿片受体介导的抗惊厥特性。总之，作为抗惊厥剂的内源性阿片肽缺乏可能在El小鼠癫痫发作的病因或病理生理学中起重要作用。
