McNamara J O, Bonhaus D W, Shin C, Crain B J, Gellman R L, Giacchino J L
CRC Crit Rev Clin Neurobiol. 1985;1(4):341-91.
Kindling is an animal model of epilepsy induced by electrical stimulation of the brain. This model has attracted the interest of many neuroscientists, in part because it involves a robust, permanent modification of brain function. This report will describe the kindling phenomenon and critically review current understanding of the underlying mechanisms. The review will carefully consider whether this model accurately reflects analogous processes in humans. The review will consider some hypotheses inspired by the kindling studies which may be relevant to human epilepsy.
点燃效应是一种通过脑电刺激诱发的癫痫动物模型。该模型引起了许多神经科学家的兴趣，部分原因是它涉及到对脑功能的强大而持久的改变。本报告将描述点燃效应现象，并批判性地回顾目前对其潜在机制的理解。该综述将仔细考虑该模型是否准确反映了人类的类似过程。该综述还将考虑一些受点燃效应研究启发的、可能与人类癫痫相关的假说。
