新城疫与传染性支气管炎混合活疫苗对鸡呼吸道的影响

The effect of mixed live vaccines of Newcastle disease and infectious bronchitis on the chicken respiratory tract.

作者信息

Nakamura K, Narita M, Imai K, Matsumura T, Maeda M, Tanimura T

机构信息

Poultry Disease Laboratory, National Institute of Animal Health, Gifu, Japan.

出版信息

J Comp Pathol. 1992 May;106(4):341-50. doi: 10.1016/0021-9975(92)90020-u.

DOI:10.1016/0021-9975(92)90020-u

PMID:1322945

Abstract

The effect of mixed live vaccines of Newcastle disease (ND) and infectious bronchitis (IB) on specific pathogen-free chickens aged 7 days was investigated. The chickens were inoculated intranasally with mixed live vaccines with and without Escherichia coli, or with E. coli alone. "Vaccine 1" consisted of ND virus strain B1 and IB virus strain ON; "vaccine 2" consisted of ND virus strain B1 and IB virus strain H120. The tracheas of chickens inoculated with the vaccines and E. coli and with the vaccines alone showed multiplication of E. coli and histological lesions (loss of cilia, degeneration and hyperplasia in epithelial cells and cellular infiltration of subepithelial tissues). In the tracheas of chickens inoculated with vaccines and E. coli, multiplication of E. coli was greater than in chickens given vaccine alone. There were no histological lesions, and only mild, transient multiplication of E. coli in chickens inoculated with E. coli alone. The results suggest that these mixed live vaccines, especially vaccine 2, play a role in inducing or enhancing colibacillosis in the chicken.

摘要

研究了新城疫（ND）和传染性支气管炎（IB）混合活疫苗对7日龄无特定病原体鸡的影响。给鸡经鼻接种含或不含大肠杆菌的混合活疫苗，或仅接种大肠杆菌。“疫苗1”由新城疫病毒B1株和传染性支气管炎病毒ON株组成；“疫苗2”由新城疫病毒B1株和传染性支气管炎病毒H120株组成。接种疫苗和大肠杆菌以及仅接种疫苗的鸡的气管显示出大肠杆菌增殖和组织学损伤（纤毛丧失、上皮细胞变性和增生以及上皮下组织细胞浸润）。在接种疫苗和大肠杆菌的鸡的气管中，大肠杆菌的增殖比仅接种疫苗的鸡更明显。仅接种大肠杆菌的鸡没有组织学损伤，且只有轻微、短暂的大肠杆菌增殖。结果表明，这些混合活疫苗，尤其是疫苗2，在诱发或增强鸡的大肠杆菌病方面起作用。