GERMUTH F G, PACE M G, TIPPETT J C
J Exp Med. 1955 Feb 1;101(2):135-50. doi: 10.1084/jem.101.2.135.
Sensitization of rabbits with bovine albumin and the cross-reactive antigen, egg albumin, increased the rate of bovine albumin elimination following its intravenous administration. Elimination of this antigen was complete in 7 and 10 days respectively instead of approximately 2 weeks as in unsensitized normal animals. The peak incidence of allergic tissue alteration was proportionately accelerated. Certain qualitative and quantitative differences between the histologic responses of the sensitized and unsensitized rabbits were noted. These differences were probably due to the shorter period of antigen-antibody interaction in the sensitized animals in which the antigen was quickly eliminated. The temporal relationship between the histologic and immunologic responses in sensitized animals adds further support to the hypothesis that the lesions which occur after the injection of foreign protein are the result of antigen-antibody combination.
用牛血清白蛋白和交叉反应抗原卵清蛋白对家兔进行致敏，会增加静脉注射牛血清白蛋白后的清除率。这种抗原的清除分别在7天和10天内完成，而不是像未致敏的正常动物那样大约需要2周。过敏组织改变的高峰发生率相应加快。观察到致敏和未致敏家兔的组织学反应在某些定性和定量方面存在差异。这些差异可能是由于致敏动物中抗原-抗体相互作用的时间较短，抗原被迅速清除。致敏动物组织学和免疫反应之间的时间关系进一步支持了这样一种假说，即注射外源蛋白后出现的病变是抗原-抗体结合的结果。
