Gharib A, Delton I, Lagarde M, Sarda N
INSERM U352, INSA, Laboratoire de Chimie Biologique, Villeurbanne, France.
Eur J Pharmacol. 1992 Apr 10;225(4):359-60. doi: 10.1016/0922-4106(92)90113-a.
We describe the effects of 5'-N-ethylcarboxamidoadenosine (NECA), a mixed A2a/A2b adenosine receptor agonist and 2-[p-(carboxyethyl)-phenylethylamino]-5'-N-ethylcarboxamidoaden osin e (CGS 21680), a selective A2a agonist, on cyclic AMP and N-acetylserotonin synthesis in rat pineal gland. NECA, 1 and 10 microM, increased cyclic AMP by 5- and 25-fold and N-acetylserotonin by 40- and 60-fold respectively, whereas CGS 21680 at the same concentrations was ineffective. These results argue for the presence of adenosine A2b receptors in rat pinealocytes.
我们描述了5'-N-乙基甲酰胺基腺苷（NECA，一种A2a/A2b腺苷受体混合激动剂）和2-[对-(羧乙基)-苯乙氨基]-5'-N-乙基甲酰胺基腺苷（CGS 21680，一种选择性A2a激动剂）对大鼠松果体中环磷酸腺苷（cAMP）和N-乙酰血清素合成的影响。1微摩尔和10微摩尔的NECA分别使cAMP增加了5倍和25倍，使N-乙酰血清素增加了40倍和60倍，而相同浓度的CGS 21680则无作用。这些结果表明大鼠松果体细胞中存在腺苷A2b受体。
