脊髓灰质炎病毒多肽2C的氨基酸残基187在决定胍特性中的作用。

Role of amino acid residue 187 of poliovirus polypeptide 2C in determining the guanidine trait.

作者信息

Baltera R F, Tershak D R

机构信息

Department of Molecular and Cell Biology, Pennsylvania State University, University Park 16802.

出版信息

Intervirology. 1992;33(3):165-72. doi: 10.1159/000150246.

DOI:10.1159/000150246

PMID:1323552

Abstract

Although mutations in codons 164 and 179 of poliovirus polypeptide 2C can establish guanidine resistance, the majority of guanidine-resistant and guanidine-dependent viruses contain an M----L change at amino residue 187 along with other critical mutations. The change at residue 187 probably contributes to the guanidine phenotype along with a variety of other modifications in polypeptide 2C, possibly altering conformation of the polypeptide during the initiation step of viral RNA synthesis.

摘要

尽管脊髓灰质炎病毒多肽2C的密码子164和179中的突变可产生胍抗性，但大多数胍抗性和胍依赖性病毒在氨基酸残基187处存在M----L变化以及其他关键突变。残基187处的变化可能与多肽2C中的多种其他修饰一起导致胍表型，可能在病毒RNA合成起始步骤中改变多肽的构象。