依赖胍的1型脊髓灰质炎病毒克隆库中对胍抗性回复突变的频率非常高。
Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus.
作者信息
de la Torre J C, Wimmer E, Holland J J
机构信息
Institute of Molecular Genetics, University of California, San Diego, La Jolla 92093.
出版信息
J Virol. 1990 Feb;64(2):664-71. doi: 10.1128/JVI.64.2.664-671.1990.
Abstract
We have carefully examined the frequency of guanidine-resistant revertants in six different clonal pools of guanidine-dependent mutants of type 1 poliovirus. The mutation frequency was (6.5 +/- 6.3) x 10(-4) (with all amino acid substitutions occurring at position 227). The minimal corrected base substitution frequency per single nucleotide site in the codon for amino acid 227 was (2.1 +/- 1.9) x 10(-4).
摘要
我们仔细检测了1型脊髓灰质炎病毒胍依赖性突变体的六个不同克隆库中胍抗性回复突变体的频率。突变频率为(6.5±6.3)×10⁻⁴（所有氨基酸替换均发生在第227位）。氨基酸227密码子中每个单核苷酸位点的最小校正碱基替换频率为(2.1±1.9)×10⁻⁴。
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