Brown D R, Bryan J T, Rodriguez M, Katz B P
Division of Infectious Diseases, Indiana University School of Medicine, Indianapolis 46202-5124.
J Infect Dis. 1992 Sep;166(3):512-7. doi: 10.1093/infdis/166.3.512.
The E4 and L1 gene products of human papillomavirus (HPV) types 6 and 11 are detected in variable amounts in condylomata acuminata. To study factors associated with detection of these proteins, biopsy specimens containing HPV-6 or -11 were analyzed for E4 protein, L1 protein, and HPV copy number. Seventeen of 50 women biopsied were pregnant. Nine men were also biopsied. Both the E4 and L1 proteins were found more frequently in lesions from pregnant women than from nonpregnant women or men. Both proteins were more often detected in lesions from women than from men. E4 gene products were more often detected in lesions in which L1 protein was detected and a higher HPV copy number was present. Detection of E4 gene products correlates with the detection of L1 protein in condylomata acuminata caused by HPV-6 or -11.
在尖锐湿 疣中可检测到不同含量的人乳头瘤病毒（HPV）6型和11型的E4和L1基因产物。为研究与这些蛋白质检测相关的因素，对含有HPV-6或-11的活检标本进行E4蛋白、L1蛋白和HPV拷贝数分析。50名接受活检的女性中有17名怀孕。9名男性也接受了活检。与未怀孕女性或男性的病变相比，E4和L1蛋白在孕妇病变中更常被发现。这两种蛋白在女性病变中比在男性病变中更常被检测到。在检测到L1蛋白且HPV拷贝数较高的病变中，E4基因产物更常被检测到。在由HPV-6或-11引起的尖锐湿 疣中，E4基因产物的检测与L1蛋白的检测相关。
