Krasnova E I
Farmakol Toksikol. 1975 Nov-Dec;38(6):687-90.
Experiments staged with rabbits, cats, frogs and chicken have proved tetracarboxylic acid dibenzosulphoethylate-bis (para-piperidinophenol)-diimidonaphthalene-1, 4, 5, (see article) to be capable of totally blocking the neuro-muscular conduction in a dose of 0.5 mg/kg and to block 20 per cent of it in a dose of 0.3 mg/kg. The action of the compound on the arterial pressure is half as great as that of d-tubocurarine. A pharmacological analysis conducted on the musculus rectus abdominus of the frog and chicken points to an antidepolarizing type of action. The durarolike effect of (see article) can be averted or abolished by introduction of nivalin (galanthamine), proserine and pimadine. The author deems it expedient to make clinical trials of the drug.
用兔子、猫、青蛙和鸡进行的实验已证明，二苯磺酰乙基四羧酸 - 双（对 - 哌啶基苯酚） - 二亚氨基萘 -1,4,5（见文章）在剂量为0.5毫克/千克时能够完全阻断神经肌肉传导，在剂量为0.3毫克/千克时能阻断20%。该化合物对动脉血压的作用是d - 筒箭毒碱的一半。对青蛙和鸡的腹直肌进行的药理分析表明其作用类型为抗去极化型。（见文章）的箭毒样作用可通过引入尼瓦林（加兰他敏）、毒扁豆碱和匹马丁来避免或消除。作者认为对该药物进行临床试验是适宜的。
