Hoso M, Nakanuma Y
Second Department of Pathology, Kanazawa University School of Medicine, Japan.
Liver. 1992 Jun;12(3):112-5. doi: 10.1111/j.1600-0676.1992.tb00567.x.
The proliferative activity of Mallory bodies (MB)-positive hepatocytes (neoplastic and non-neoplastic) was examined by counting the argyrophilic nucleolar organizer regions (AgNORs). Among 19 cases of hepatocellular carcinoma, the mean number of AgNORs was lower in the MB-positive carcinoma cells than in the negative ones in nine cases, higher in six, and there was no difference in four. In non-neoplastic cases (seven cases of advanced primary biliary cirrhosis and seven cases of alcoholic or nutritional liver injury), the mean number of AgNORs was lower in the MB-positive hepatocytes than that in the negative ones in eight cases, and approximately equal in number in six cases. These findings imply that MB formation does not directly represent the level of proliferative activity of hepatocytes, regardless of whether they are malignant or not.
通过计数嗜银核仁组织区（AgNORs）来检测马洛里小体（MB）阳性肝细胞（肿瘤性和非肿瘤性）的增殖活性。在19例肝细胞癌中，9例MB阳性癌细胞的AgNORs平均数低于阴性癌细胞，6例高于阴性癌细胞，4例无差异。在非肿瘤性病例（7例晚期原发性胆汁性肝硬化和7例酒精性或营养性肝损伤）中，8例MB阳性肝细胞的AgNORs平均数低于阴性肝细胞，6例数量大致相等。这些发现表明，无论肝细胞是恶性还是良性，MB的形成并不直接代表其增殖活性水平。
