血液透析患者群体中丙型肝炎的流行病学

Epidemiology of hepatitis C in a population of hemodialysis patients.

作者信息

Mosconi G, Campieri C, Miniero R, Colì L, Orsi C, La Manna G, De Sanctis L B, Stefoni S, Sprovieri G, Bonomini V

机构信息

Institute of Nephrology, S. Orsola University Hospital, Bologna, Italy.

出版信息

Nephron. 1992;61(3):298-9. doi: 10.1159/000186911.

DOI:10.1159/000186911

PMID:1323773

Abstract

A search for antibodies against hepatitis C virus (HCV) was performed in 185 patients on chronic hemodialysis by means of 1st and 2nd generation ELISA tests. Immunoblot assays were performed on positive sera. This study shows a 38% prevalence of HCV-positive patients in our dialysis population according to the 2nd generation ELISA test which shows a higher specificity and sensitivity when compared to the 1st generation one (38 vs. 20%). A correlation was found between the prevalence of HCV-positive patients and how long they had been on dialysis and how many blood transfusions they had received.

摘要

通过第一代和第二代酶联免疫吸附测定（ELISA）检测，对185例慢性血液透析患者进行了抗丙型肝炎病毒（HCV）抗体检测。对阳性血清进行了免疫印迹分析。本研究显示，根据第二代ELISA检测，我们透析人群中HCV阳性患者的患病率为38%，与第一代相比，第二代检测具有更高的特异性和敏感性（38%对20%）。发现HCV阳性患者的患病率与他们接受透析的时间长短以及接受输血的次数之间存在相关性。