Rinner I, Schauenstein K, Mangge H, Porta S, Kvetnansky R
Institute of Functional Pathology, University of Graz, Austria.
Brain Behav Immun. 1992 Jun;6(2):130-40. doi: 10.1016/0889-1591(92)90013-e.
The effects of short-term handling and different durations of immobilization on serum levels of catecholamines, ACTH, prolactin, and corticosterone and in vitro functions of lymphocytes were examined in rats. The results show that changes in the immune response of peripheral blood lymphocytes (PBL) depend on the intensity of the stressor: Short (1 min) handling of cannulated rats induced an enhanced stimulation of PBL to respond to T and B cell mitogens, whereas immobilization of the same animals led to suppression, dependent on the time this stressor was applied. The decrease in the mitogen reactivity of PBL after 120 min of immobilization was reversible within 24 h, and could be largely prevented by adrenalectomy, confirming that factors released by this gland are mainly responsible for immunosuppression. In contrast to PBL, spleen cells showed an enhanced mitogen response to immobilization and adrenalectomy, indicating that the immune response is differently regulated in the various compartments of the immune system. Possible correlations of the various effects with changes in stress hormone levels are discussed.
在大鼠中研究了短期处理和不同时长的固定对血清儿茶酚胺、促肾上腺皮质激素、催乳素和皮质酮水平以及淋巴细胞体外功能的影响。结果表明，外周血淋巴细胞（PBL）免疫反应的变化取决于应激源的强度：对插管大鼠进行短时间（1分钟）处理会增强PBL对T和B细胞有丝分裂原反应的刺激，而对相同动物进行固定则会导致抑制，这取决于施加该应激源的时间。固定120分钟后PBL有丝分裂原反应性的降低在24小时内是可逆的，并且肾上腺切除可在很大程度上预防这种降低，这证实了该腺体释放的因子是免疫抑制的主要原因。与PBL不同，脾细胞对固定和肾上腺切除表现出增强的有丝分裂原反应，表明免疫系统的各个部分中免疫反应的调节方式不同。讨论了各种效应与应激激素水平变化之间可能的相关性。
