STARZL T E, GAERTNER R A
Circulation. 1955 Aug;12(2):259-70. doi: 10.1161/01.cir.12.2.259.
A method is described for the production of chronic atrioventricular block in dogs, by incision of the region of the bundle of His through the open right atrium during temporary caval occlusion. Exercise tolerances, chest x-ray films, electrocardiograms, phonocardiograms, cardiac outputs, intracardiac pressures, femoral pressures, and left ventricular coronary flows were obtained preoperatively and from 1 to 10 months postoperatively. The majority of the animals developed clinical, laboratory, and pathological evidence of congestive heart failure. All animals had generalized myocardial hypertrophy.
描述了一种在犬类中制造慢性房室传导阻滞的方法，即在临时腔静脉闭塞期间通过开放的右心房切开希氏束区域。在术前以及术后1至10个月获取运动耐量、胸部X光片、心电图、心音图、心输出量、心内压力、股动脉压力和左心室冠状动脉血流量。大多数动物出现了充血性心力衰竭的临床、实验室和病理证据。所有动物均有全身性心肌肥大。
