Boucher M, Duchene-Marullaz P
J Pharmacol Methods. 1985 Apr;13(2):95-107. doi: 10.1016/0160-5402(85)90053-1.
This paper reviews methods for producing experimental complete atrioventricular (A-V) block in dogs, with emphasis on those methods that enable chronic A-V block to be obtained. The dog with chronic complete A-V block, particularly when unanesthetized, is a useful experimental model, and the production of complete A-V block is an approach to the clinical treatment of certain supraventricular arrhythmias. Criteria for the choice of method are discussed, and the results obtained to date in the unanesthetized dog with chronic A-V block are briefly described to illustrate the usefulness of this experimental model.
本文综述了在犬类中产生实验性完全性房室传导阻滞的方法，重点介绍了那些能够实现慢性房室传导阻滞的方法。患有慢性完全性房室传导阻滞的犬，尤其是在未麻醉状态下，是一种有用的实验模型，而完全性房室传导阻滞的产生是治疗某些室上性心律失常的一种临床方法。文中讨论了选择方法的标准，并简要描述了迄今为止在未麻醉的慢性房室传导阻滞犬身上获得的结果，以说明该实验模型的实用性。
